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möglich sobald bei der ZB eingereicht worden ist.
A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus.
EMBO J. 12, 3921-3929 (1993)
oriLyt, the lytic origin of DNA replication of Epstein-Barr virus (EBV), ensures viral DNA amplification during the productive or lytic phase of the virus' life cycle. To understand the contribution of cis- and transacting elements involved in DNA replication of oriLyt, a detailed mutational analysis was undertaken which defined BZLF1, a viral transcriptional activator, as an essential replication factor. The BZLF1 protein belongs to the extended fos/jun family of transcription factors and binds to specific BZLF1 binding motifs within oriLyt, as well as to consensus AP-1 sites. Recombinant, chimeric transcription factors identified the transcriptional activation domain of BZLF1 as being necessary to mediate DNA replication, a function which could not be substituted by any other transcription factor tested, including jun, E2, myc or VP16.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
1993
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Zeitschrift
EMBO Journal, The
Quellenangaben
Band: 12,
Heft: 10,
Seiten: 3921-3929
Verlag
Wiley
Verlagsort
Heidelberg, Germany
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Research Unit Gene Vector (AGV)
Research Unit Gene Vector (AGV)
POF Topic(s)
30203 - Molecular Targets and Therapies
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
Immune Response and Infection
PSP-Element(e)
G-501500-002
Scopus ID
0027282974
Erfassungsdatum
1993-12-31