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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Aerosol delivery during mechanical ventilation to the rat.
Exp. Lung Res. 30, 635-651 (2004)
The authors have adjusted a jet nebulizer to a mechanical ventilator (Servo Ventilator, Siemens) to deliver an aerosol to rats. They aimed to clarify whether a modified jet nebulizer generating particles with a mass median aerodynamic diameter of 2 µm would be effective and safe in intubated ventilated rats. Fluorescent microspheres (diameter: 1.0 µm) were aerosolized to verify qualitatively and quantitatively intrapulmonary deposition. Particle deposition fraction was 3.8% (1.3%) of the delivered dose (median [interquartile range]). There was no evidence for any adverse event as assessed from heart rate, mean arterial pressure, PaO2 and PaCO2 before, during, and after nebulization. No pulmonary tissue trauma was detected histologically.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
aerosol; animal experimentaion; nebulizers
ISSN (print) / ISBN
0190-2148
e-ISSN
1521-0499
Zeitschrift
Experimental Lung Research
Quellenangaben
Band: 30,
Heft: 7,
Seiten: 635-651
Verlag
Informa Healthcare
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Biology (LHI)