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Reininger, C.B.* ; Lasser, R. ; Rumitz, M.* ; Böger, C.* ; Schweiberer, L.*

Computational analysis of platelet adhesion and aggregation under stagnation point flow conditions.

Comput. Biol. Med. 29, 1-18 (1999)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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The clinical relevance of platelet function assessment with stagnation point flow adhesio-aggregometry (SPAA) has been verified. Quantitative analysis of platelet adhesion and aggregation is possible by means of mathematical analysis of the dark-field, light intensity curves (growth curves) obtained during the SPAA experiment. We present a computational procedure for evaluating these curves, which was necessitated by, and is based on, actual clinical application. A qualitative growth curve classification, corresponding to a basic and distinct pattern of platelet deposition and characteristic of a regularly occurring clinical state is also presented.

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