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Simon, H.-U.* ; Plötz, S.G. ; Simon, D.* ; Dummer, R.* ; Blaser, K.*

Clinical and Immunological Features of Patients with Interleukin-5-Producing T Cell Clones and Eosinophilia.

Int. Arch. Allergy Immunol. 124, 242-245 (2001)
DOI
Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Clonal T cells Eosinophils Hypereosinophilia Immunophenotype Interleukin-5
ISSN (print) / ISBN 1018-2438
e-ISSN 1423-0097
Zeitschrift International Archives of Allergy and Immunology
Quellenangaben Band: 124, Heft: 1-3, Seiten: 242-245 Artikelnummer: , Supplement: ,
Verlag Karger
Verlagsort Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; Bangalore ; Bangkok ; Singapore ; Tokyo ; Sydney
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)