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Nimmerjahn, F. ; Milosevic, S. ; Behrends, U. ; Jaffee, E.M.* ; Pardoll, D.M.* ; Bornkamm, G.W. ; Mautner, J.

Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy.

Eur. J. Immunol. 33, 1250-1259 (2003)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from the cytosolic protein neomycin phosphotransferase II (NeoR) on MHC classII is mediated by autophagy. This presentation pathway involves the sequestration of NeoR into autophagosomes, and subsequent delivery into the lytic compartment. These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Antigen presentation Human MHC T lymphocyte
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Zeitschrift European Journal of Immunology
Quellenangaben Band: 33, Heft: 5, Seiten: 1250-1259 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)