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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Dendritic Cells under Influence of Mouse Cytomegalovirus Have a Physiologic Dual Role : To Initiative and to Restrict T Cell Activation.
J. Infect. Dis. 187, 988-999 (2003)
The aim of this study is to analyze the dynamics of the mouse cytomegalovirus (MCMV)-dendritic cell (DC) interaction. Immature and mature DCs derived from the mouse stem cell line factor-dependent cell Paterson mixed potential were infected with a recombinant MCMV expressing green fluorescent protein. Infection of immature DCs resulted in DC activation and virus production, both of which may contribute to viral dissemination. The infection of mature DCs was nonproductive and was restricted to immediate-early and early viral protein expression. During early stages of MCMV infection, mature DCs up-regulated major histocompatibility complex (MHC) and costimulatory molecules and activated autologous, but not allogeneic, naive T cells. At later times of MCMV infection, DCs prevented T cell activation by down-regulation of MHC and costimulatory molecules. Thus, DCs under the influence of MCMV have a physiologic dual role: to initiate and to restrict T cell activation. The lack of immunostimulation in allogeneic settings may explain the increased risk of MCMV morbidity after allogeneic transplantation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
BONE-MARROW TRANSPLANTATION; SIMPLEX VIRUS TYPE-1; CLASS-II EXPRESSION; MURINE CYTOMEGALOVIRUS; HERPESVIRUS GENOME; CROSS-PRESENTATION; IMMUNE-RESPONSE; GLYCOPROTEIN-B; PP65 UL83; INFECTION
ISSN (print) / ISBN
0022-1899
e-ISSN
1537-6613
Zeitschrift
Journal of Infectious Diseases, The
Quellenangaben
Band: 187,
Heft: 6,
Seiten: 988-999
Verlag
Oxford University Press
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed