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Association Study Between CAG Trinucleotide Repeats in the PCQAP Gene (PC2 Glutamine/Q- Rich-Associated Protein) and Schizophrenia.
Am. J. Med. Genet. B 116, 32-35 (2003)
Schizophrenia or schizoaffective disorders are quite common features in patients with DiGeorge/velocardiofacial syndrome (DGS/VCFS) as a result of hemizygosity of chromosome 22q11.2. We evaluated the PCQAP gene, which maps within the DGS/VCFS interval, as a potential candidate for schizophrenia susceptibility. PCQAP encodes for a subunit of the large multiprotein complex PC2, which exhibits a coactivator function in RNA polymerase II mediated transcription. Using a case–control study, we searched association between schizophrenia and the intragenic coding trinucleotide polymorphism. The distribution of the CAG repeat alleles was significantly different between patients and controls with the Mann-Whitney test (z = −2.5694, P = 0.0051; schizophrenics: n = 378, W = 161,002.5, Mean rank = 425.9325; controls: n = 444, W = 177,250.5, Mean rank = 399.2128). This result may indicate a possible involvement of the multiprotein complex PC2 in schizophrenia susceptibility.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
velo-cardio-facial syndrome DiGeorge syndrome deletion 22q11 polyglutamine transcription factors psychosis case-control PC2 coactivator polymorphism PCQAP
ISSN (print) / ISBN
1552-4841
e-ISSN
0148-7299
Quellenangaben
Band: 116,
Heft: 1,
Seiten: 32-35
Verlag
Wiley
Verlagsort
Hoboken, NJ
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Immunology (IMI)