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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Activation of natural killer cells by heat shock protein 70.
Int. J. Hyperthermia 25, 169-175 (2009)
Intracellular heat shock proteins (HSP) function as molecular chaperones, they support folding and transport mechanisms of other proteins under physiological conditions and following physical or chemical stress. More recently, extracellular localized HSP have been found to play key roles in the induction of a cellular immune response. Either they act as carrier molecules for immunogenic peptides that are presented on Antigen Presenting Cells (APC) to cytotoxic T-cells or they themselves act as activatory molecules for the innate immune system. Binding of uncomplexed HSP to HSP-receptors on APC has been found to induce the secretion of inflammatory cytokines. Furthermore, an unusual tumor-selective membrane-localization of non-conserved regions of the 72 000 Da HSP (Hsp70) has been found to act as a recognition structure for natural killer (NK) cells. In this review the interaction of NK cells with Hsp70 or peptides derived thereof will be eluciated in more detail.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.339
1.060
29
43
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
NK cells; Hsp70-receptor; Hsp70 activatory peptide; tumor kill; heat-shock-protein; human tumor-cells; inducible immunogenic determinant; nk cells; antigen presentation; surface expression; t-lymphocytes; sarcoma-cells; in-vivo; receptor
Sprache
englisch
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0265-6736
e-ISSN
1464-5157
Zeitschrift
International Journal of Hyperthermia
Quellenangaben
Band: 25,
Heft: 3,
Seiten: 169-175
Verlag
Informa Healthcare
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Innate Immunity in Tumor Biology (PATH-KTB)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
PSP-Element(e)
G-521400-001
PubMed ID
19437234
Erfassungsdatum
2009-07-09