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Riedel, C.* ; von Kries, R.* ; Fenske, N.* ; Strauch, K. ; Ness, A.R.* ; Beyerlein, A.

Interactions of genetic and environmental risk factors with respect to body fat mass in children: Results from the ALSPAC study.

Obesity 21, 1238-1242 (2013)
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Open Access Green
Objective: To evaluate if percentile-specific effects of genetic, environmental and lifestyle obesity risk factors on body mass index (BMI) might reflect gene-environment interactions with respect to the development of overweight. Design and Methods: Retrospective study with data of 2,346 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), using quantile regression with body fat mass index (FMI) for children at the age of 9 years as outcome variable. We assessed interactions of an “obesity-risk-allele-score” with environmental and nutritional factors. Results: There was no evidence of interactions between the obesity-risk-allele score and the environmental variables except for maternal overweight. However, we found a significant interaction with respect to intake of mono- and polyunsaturated fatty acids at the age of 7. In children with low intake, genetic risk was associated with increasing effect sizes by FMI percentile. Conclusions: Our results suggest an interaction between a low dietary content of unsaturated fatty acids and genetic risk factors for overweight on FMI. This effect is likely to be stronger in children with higher FMI.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter ALSPAC; Child; fat mass; genetics; overweight; risk factors; Quantile Regression ; Receptor Gene ; Obesity Risk ; Metabolic Syndrome ; Energy-intake ; Japanese Men ; Polymorphism ; Childhood ; Association ; Overweight
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1930-7381
e-ISSN 1930-739X
Zeitschrift Obesity
Quellenangaben Band: 21, Heft: 6, Seiten: 1238-1242 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Diabetes Research (IDF)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
Helmholtz Diabetes Center
PSP-Element(e) G-504100-001
G-502100-001
PubMed ID 23670811
DOI 10.1002/oby.20196
WOS ID WOS:000322487000026
Scopus ID 84881369547
Erfassungsdatum 2013-03-05
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