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CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.
Cancer Biomark. 12, 97-105 (2012)
BACKGROUND: The pentaspan protein CD133 (Prominin-1) is a predictive marker and part of the signature of tumour-initiating cells (TICs) for various cancer entities. METHODS: The correlation of CD133 expression with clinical parameters was assessed in primary samples of head and neck squamous cell carcinomas (n = 98) and normal mucosas (n = 24). RESULTS: A gradual and inversely proportional correlation between CD133 expression in primary tumours and decreased overall survival was observed, along with a positive correlation with the presence of lymph node metastases. CONCLUSIONS: CD133 has the potential of being a novel clinically relevant prognostic marker for head and neck malignancies, which is possibly involved in regulation of tumourigenicity.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cd133 ; Hnsccs ; Overall Survival; Node-positive Head ; Cancer Stem-cells ; Adjuvant Radiotherapy ; Oropharyngeal Cancer ; Epidemiology ; Expression ; Protein ; Alpha
ISSN (print) / ISBN
1574-0153
e-ISSN
1875-8592
Zeitschrift
Cancer Biomarkers
Quellenangaben
Band: 12,
Heft: 2,
Seiten: 97-105
Verlag
IOS Press
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed