PuSH - Publikationsserver des Helmholtz Zentrums München: Sequential multilocus fluorescence in situ hybridization can detect complex patterns of increased gene dosage at the single cell level in tissue sections.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Walch, A.K. ; Bink, K. ; Hutzler, P. ; Böwering, K.* ; Letsiou, I.* ; Zitzelsberger, H. ; Braselmann, H. ; Stein, H.* ; Höfler, H.* ; Werner, M.

Sequential multilocus fluorescence in situ hybridization can detect complex patterns of increased gene dosage at the single cell level in tissue sections.

Lab. Invest. 81, 1457-1459 (2001)

Verlagsversion Volltext

PMC

	Closed

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Although some impressive applications of multicolor fluorescence in situ hybridization (M-FISH) have been demonstrated on cytogenetic preparations, there are no reports of studies that carry over these advanced multitarget techniques to histological sections of tumor tissues in molecular pathology. Despite recent advances in protocols, M-FISH with a simultaneous multicolor painting tool does not seem to be a feasible approach in histological sections, mainly because of the inherent problem of the third dimension, which leads to complex overlays of both fluorescence signals and nuclei of tumor cells. To overcome these technical limitations, we introduce here an innovative and robust method for the detection of multiple targets by interphase FISH in formalin-fixed and paraffin-embedded tissue, called sequential multilocus fluorescence in situ hybridization (SML-FISH).

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Altmetric

0.000