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Hölter, S.M. ; Dalke, C. ; Kallnik, M. ; Becker, L. ; Horsch, M. ; Schrewe, A. ; Favor, J. ; Klopstock, T.* ; Beckers, J. ; Ivandic, B.* ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Graw, J. ; Wurst, W.

'Sighted C3H' mice - a tool for analysing the influence of vision on mouse behaviour?

Front. Biosci. 13, 5810-5823 (2008)
Postprint DOI PMC
Open Access Green
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the Pde6b(rd1) mutation on mouse behaviour and physiology, sighted C3H (C3H.Pde6b+) and normal C3H/HeH mice were phenotyped for different aspects. We confirmed retinal degeneration 1 in C3H/HeH mice, and the presence of a morphologically normal retina as well as visual ability in C3H.Pde6b+ mice. However, C3H.Pde6b+ mice showed an abnormal retinal function in the electroretinogram response, indicating that their vision was not normal as expected. C3H.Pde6b+ mice showed reduced latencies for several behaviours without any further alterations in these behaviours in comparison to C3H/HeH mice, suggesting that visual ability, although impaired, enables earlier usage of the behavioural repertoire in a novel environment, but does not lead to increased activity levels. These results emphasize the importance of comprehensive behavioural and physiological phenotyping.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter C3H mice; Pde6b; vision; behaviour; phenotyping
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 2008
ISSN (print) / ISBN 1093-9946
e-ISSN 1093-4715
Zeitschrift Frontiers in Bioscience
Quellenangaben Band: 13, Heft: 15, Seiten: 5810-5823 Artikelnummer: , Supplement: ,
Verlag Frontiers
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
Institute of Human Genetics (IHG)
POF Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-001
G-500600-003
G-500700-002
PubMed ID 18508624
DOI 10.2741/3118
Scopus ID 52049125697
Erfassungsdatum 2008-06-24
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