PuSH - Publikationsserver des Helmholtz Zentrums München: Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema.

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Pressler, A.* ; Grosber, M. ; Halle, M.* ; Ring, J. ; Brockow, K.

Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema.

Clin. Exp. Dermatol. 38, 151-153 (2013)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Vibratory angio-oedema is a rare form of physical urticaria characterized by pruriginous weals and angio-oedema at the site of exposure to vibration. Severe treatment-resistant disease can occur, and is associated with significant disability. Therapy with omalizumab, a monoclonal IgG anti-IgE antibody, has been shown to be successful in several types of physical urticaria. We report a patient with vibratory angio-oedema for whom all standard treatments for urticaria, including omalizumab, failed to show a clinical benefit. Finally, ketotifen was tried, and unexpectedly reduced symptoms significantly. Ketotifen may thus represent a therapeutic option in patients with treatment-resistant vibratory angio-oedema.

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