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Rieger, M. ; Schroeder, T.

Analyzing cell fate control by cytokines through continuous single cell biochemistry.

J. Cell. Biochem. 108, 343-352 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cytokines are important regulators or cell fates with high clinical and commercial relevance. However, despite decades of intense academic and industrial research, it proved surprisingly difficult to describe the biological functions of cytokines in a precise and comprehensive manner. The exact analysis of cytokine biology is complicated by the fact that. individual cytokines control many different cell fates and activate a multitude of intracellular signaling pathways. Moreover, although activating different molecular programs, different cytokines can be redundant in their biological effects. In addition, cytokines with different biological effects can activate overlapping signaling pathways. This prospect article will outline the necessity of continuous single cell biochemistry to unravel the biological functions of molecular cytokine signaling. It focuses on potentials and limitations of recent technical developments in fluorescent time-lapse imaging and single cell tracking allowing constant long-term observation of molecules and behavior of single cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter HEMATOPOIESIS; CYTOKINE SIGNALING; TIME-LAPSE IMAGING; SINGLE CELL TRACKING; FRET; COLONY-STIMULATING FACTOR; PROTEIN-KINASE-C; LIVING CELLS; HEMATOPOIETIC CYTOKINES; FLUORESCENT INDICATORS; LINEAGE COMMITMENT; PLASMA-MEMBRANE; RECEPTOR; ACTIVATION; MACROPHAGE
ISSN (print) / ISBN 0730-2312
e-ISSN 1097-4644
Zeitschrift Journal of Cellular Biochemistry
Quellenangaben Band: 108, Heft: 2, Seiten: 343-352 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)