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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Equine recurrent uveitis: A spontaneous horse model of uveitis.
Ophthalmic Res. 40, 151-153 (2008)
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome. CRALBP also seems to be relevant to human autoimmune uveitis. Proteomic screening of vitreous and retinal samples from ERU diseased cases in comparison to healthy controls has led to the identification of a series of differentially regulated proteins, which are functionally linked to the immune system and the maintenance of the blood-retinal barrier
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Uveitis; spontaneous model; horse; Autoimmune; Target organ; Autoantigens; Proteomics; Regulated proteins
ISSN (print) / ISBN
0030-3747
e-ISSN
1423-0259
Zeitschrift
Ophthalmic Research
Quellenangaben
Band: 40,
Heft: 3-4,
Seiten: 151-153
Verlag
Karger
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CF Metabolomics & Proteomics (CF-MPC)