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Disparate individual fates compose robust CD8+ T cell immunity.
Science 340, 630-635 (2013)
Verlagsversion Volltext
DOI
PMC
A core feature of protective T cell responses to infection is the robust expansion and diversification of naïve antigen-specific T cell populations into short-lived effector and long-lived memory subsets. By in vivo fate mapping, we find a striking variability of immune responses derived from individual CD8+ T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. Unbiased mathematical modeling identifies the random integration of multiple differentiation and division events as the driving force behind this variability. Within this probabilistic framework, cell fate is specified along a linear developmental path that progresses from slowly proliferating long-lived to rapidly expanding short-lived subsets. These data provide insights into how complex biological systems implement stochastic processes to guarantee robust outcomes.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
31.027
8.060
255
261
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Transcription Factor ; Cutting Edge ; Memory ; Effector ; Precursor ; Subsets ; Stem ; Differentiation ; Expansion ; Division
Sprache
englisch
Veröffentlichungsjahr
2013
HGF-Berichtsjahr
2013
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Zeitschrift
Science
Quellenangaben
Band: 340,
Heft: 6132,
Seiten: 630-635
Verlag
American Association for the Advancement of Science (AAAS)
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-502700-001
G-502700-003
G-501790-002
G-520100-001
G-501790-003
G-502700-003
G-501790-002
G-520100-001
G-501790-003
WOS ID
WOS:000318268900053
PubMed ID
23493420
Erfassungsdatum
2013-04-22