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Eberl, H.J.* ; Khassehkhan, H.* ; Demaret, L.

A mixed-culture model of a probiotic biofilm control system.

Comput. Math. Methods Med. 11, 99-118 (2010)
Verlagsversion DOI
Open Access Gold
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We present a mathematical model and computer simulations for the control of a pathogenic biofilm by a probiotic biofilm. This is a substantial extension of a previous model of control of a pathogenic biofilm by microbial control agents that are suspended in the aqueous bulk phase (H. Khassehkhan and H.J. Eberl, Comp. Math. Meth. Med, 9(1) (2008), pp. 47-67). The mathematical model is a system of double-degenerate diffusion-reaction equations for the microbial biomass fractions probiotics, pathogens and inert bacteria, coupled with convection-diffusion-reaction equations for two growth controlling substrates, protonated lactic acids and hydrogen ions (pH). The latter are produced by the bacteria and become detrimental at high concentrations. In simulation studies, we find that the site of attachment of probiotics in the flow channel is crucial for success and efficacy of the probiotic control mechanism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter biofilm; probiotics; mathematical model; nonlinear diffusion; simulation
ISSN (print) / ISBN 1748-670X
e-ISSN 1748-6718
Zeitschrift Computational and Mathematical Methods in Medicine
Quellenangaben Band: 11, Heft: 2, Seiten: 99-118 Artikelnummer: , Supplement: ,
Verlag Hindawi
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biomathematics and Biometry (IBB)