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Gräber, M.* ; Hell, M.* ; Grost, C.* ; Friberg, A. ; Sperl, B.* ; Sattler, M. ; Berg, T.*

Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.

Angew. Chem.-Int. Edit. 52, 4487-4491 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein-protein interactions is a potential mode of action of drugs in current human use. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Antitumor Agents ; Apoptosis ; Drug Discovery ; Inhibitors ; Protein-protein Interactions; Bcl-2 Family ; Fluorescence Polarization ; Antagonists ; Optimization ; Recognition ; Antiseptics ; Alexidine ; Domains ; Assay
ISSN (print) / ISBN 1433-7851
e-ISSN 1521-3773
Zeitschrift Angewandte Chemie - Internationale Edition
Quellenangaben Band: 52, Heft: 16, Seiten: 4487-4491 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)