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Padeken, J.* ; Mendiburo, M.J.* ; Chlamydas, S.* ; Schwarz, H.J.* ; Kremmer, E. ; Heun, P.*

The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.

Mol. Cell 50, 236-249 (2013)
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Centromere clustering during interphase is a phenomenon known to occur in many different organisms and cell types, yet neither the factors involved nor their physiological relevance is well understood. Using Drosophila tissue culture cells and flies, we identified a network of proteins, including the nucleoplasmin-like protein (NLP), the insulator protein CTCF, and the nucleolus protein Modulo, to be essential for the positioning of centromeres. Artificial targeting further demonstrated that NLP and CTCF are sufficient for clustering, while Modulo serves as the anchor to the nucleolus. Centromere clustering was found to depend on centric chromatin rather than specific DNA sequences. Moreover, unclustering of centromeres results in the spatial destabilization of pericentric heterochromatin organization, leading to partial defects in the silencing of repetitive elements, defects during chromosome segregation, and genome instability.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Position-effect Variegation ; Drosophila-melanogaster ; Nuclear Periphery ; Chromatin ; Ctcf ; Protein ; Heterochromatin ; Nucleophosmin ; Localization ; Organization
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1097-2765
e-ISSN 1097-4164
Zeitschrift Molecular Cell
Quellenangaben Band: 50, Heft: 2, Seiten: 236-249 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501793-001
PubMed ID 23562326
DOI 10.1016/j.molcel.2013.03.002
WOS ID WOS:000318208600009
Scopus ID 84876879922
Erfassungsdatum 2013-05-31
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