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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.
Mol. Cell 50, 236-249 (2013)
Centromere clustering during interphase is a phenomenon known to occur in many different organisms and cell types, yet neither the factors involved nor their physiological relevance is well understood. Using Drosophila tissue culture cells and flies, we identified a network of proteins, including the nucleoplasmin-like protein (NLP), the insulator protein CTCF, and the nucleolus protein Modulo, to be essential for the positioning of centromeres. Artificial targeting further demonstrated that NLP and CTCF are sufficient for clustering, while Modulo serves as the anchor to the nucleolus. Centromere clustering was found to depend on centric chromatin rather than specific DNA sequences. Moreover, unclustering of centromeres results in the spatial destabilization of pericentric heterochromatin organization, leading to partial defects in the silencing of repetitive elements, defects during chromosome segregation, and genome instability.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Position-effect Variegation ; Drosophila-melanogaster ; Nuclear Periphery ; Chromatin ; Ctcf ; Protein ; Heterochromatin ; Nucleophosmin ; Localization ; Organization
ISSN (print) / ISBN
1097-2765
e-ISSN
1097-4164
Zeitschrift
Molecular Cell
Quellenangaben
Band: 50,
Heft: 2,
Seiten: 236-249
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Immunology (IMI)