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Oestreicher, U.* ; Braselmann, H. ; Stephan, G.*

Cytogenetic analysis in peripheral lymphocytes of persons living in houses with increased levels of indoor radon concentrations.

Cytogenet. Genome Res. 104, 232-236 (2004)
DOI
Published data concerning the effects of indoor radon exposure on the frequency of chromosome aberrations in peripheral lymphocytes of residents are contradictory. Possible reasons for this may be the low radon concentration in dwellings and/or the limited number of investigated persons. We therefore studied the relationship of domestic radon exposure and the occurrence of chromosome aberrations in peripheral lymphocytes in 61 persons living in houses with radon concentrations from 80 up to 13,000 Bq/m3. We analyzed 60,000 cells from fluorescence plus Giemsa (FPG)-stained slides. It could be clearly demonstrated that in groups of persons living in dwellings with indoor radon concentrations >200 Bq/m3 the number of cells containing dicentrics and/or centric rings (Cdic + cr) (2.45 ± 0.50 × 10–3) was significantly increased (p < 0.05) in comparison to the control level (1.03 ± 0.15 × 10–3). However, there was no difference in the mean frequency of Cdic + cr between the groups living in dwellings with higher radon concentrations. Using the fluorescence in situ hybridization (FISH) technique for the detection of translocations, we analyzed 23,315 cells in 16 persons of the highest exposed group (>5,000 Bq/m3). The observed frequency of translocations was 3.9 ± 0.64 × 10–3. In comparison to the control group (2.02 ± 0.18 × 10–3), there was a slight but not statistically significant increase in the exposed group (P = 0.055). If, however, the age of the examined persons is taken into account, the values are significantly increased (P < 0.05) in the exposed persons older than 40 years in comparison to the age-matched controls. Since most of the translocations were found in stable cells, it is concluded that translocations are also induced in blood-forming tissue and are transmitted to peripheral blood. 
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0301-0171
e-ISSN 1421-9816
Zeitschrift Cytogenetic and Genome Research
Quellenangaben Band: 104, Heft: 1-4, Seiten: 232-236 Artikelnummer: , Supplement: ,
Verlag Karger
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Radiation Biology (IMS)