PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Enciso-Mora, V.* ; Hosking, F.J.* ; Kinnersley, B.* ; Wang, Y.F.* ; Shete, S.* ; Zelenika, D.* ; Broderick, P.* ; Idbaih, A.* ; Delattre, J.-Y.* ; Hoang-Xuan, K.* ; Marie, Y.* ; di Stefano, A.L.* ; Labussière, M.* ; Dobbins, S.* ; Boisselier, B.* ; Ciccarino, P.* ; Rossetto, M.* ; Armstrong, G.* ; Liu, Y.H.* ; Gousias, K.* ; Schramm, J.* ; Lau, C.* ; Hepworth, S.J.* ; Strauch, K. ; Müller-Nurasyid, M. ; Schreiber, S.* ; Franke, A.* ; Moebus, S.* ; Eisele, L.* ; Försti, A.* ; Hemminki, K.* ; Tomlinson, I.P.* ; Swerdlow, A.* ; Lathrop, M* ; Simon, M.* ; Bondy, M.* ; Sanson, M.* ; Houlston, R.S.*

Deciphering the 8q24.21 association for glioma.

Hum. Mol. Genet. 22, 2293-2302 (2013)
Verlagsversion Volltext DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequencing data generated on 253 individuals. Analysis revealed an imputed low-frequency SNP rs55705857 (P = 2.24 x 10(-38)) which was sufficient to fully capture the 8q24.21 association. Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 x 10(-67)). Validation of the non-GBM association was shown in three additional datasets (625 non-GBM cases, 2412 controls; P = 1.41 x 10(-28)). In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 x 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. These data provide additional insights into the aetiological basis of glioma development.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.692
1.762
25
31
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter GENOME-WIDE ASSOCIATION; RISK; POPULATION; EXPRESSION; CANCER; TUMORS; PROFILES; KORA
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 22, Heft: 11, Seiten: 2293-2302 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
G-504090-001
PubMed ID 23399484
DOI 10.1093/hmg/ddt063
WOS ID WOS:000319432000015
Scopus ID 84877898030
Erfassungsdatum 2013-06-28
[➜Korrektur melden]