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Schulte, E.C. ; Gross, N.* ; Slawik, H.* ; Winkelmann, J.

When restless legs syndrome turns malignant.

Sleep Med. 14, 575-577 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Usually symptoms of restless legs syndrome (RLS) respond well to treatment with dopaminergic drugs, opiates, or anticonvulsant medications. Yet sometimes symptoms can be severe and become refractory, even to high-dose combination therapy. Here we present two cases of familial RLS with rigorous and unusual motor and sensory symptoms in the form of episodes of myoclonic hyperkinesias and painful sensations in addition to more characteristic features of RLS. Stepwise reduction of all RLS-and antidepressant medication down to opiate monotherapy-and subsequent opiate rotation led to an improvement of symptoms. Yet in both cases, reintroduction of low-dose dopaminergic drugs was necessary to achieve satisfactory treatment effect. We have termed this form of RLS refractory to multiple combinations of all classes of commonly used drugs malignant RLS. Therapeutically simplification and reduction of the drug scheme and opiate rotation should be considered in malignant RLS.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Restless legs syndrome; Malignant restless legs syndrome; Paroxysmal myoclonic attacks; Opiate rotation; De-escalation of therapy; Multidrug therapy; DOUBLE-BLIND; AUGMENTATION; TRAMADOL; PLACEBO
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1389-9457
e-ISSN 1878-5506
Zeitschrift Sleep Medicine
Quellenangaben Band: 14, Heft: 6, Seiten: 575-577 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500700-001
PubMed ID 23643657
DOI 10.1016/j.sleep.2013.02.012
WOS ID WOS:000319502300016
Scopus ID 84876815335
Erfassungsdatum 2013-06-28
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