Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
Verlagsversion Volltext
DOI
PMC
 |
Free by publisher |
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.
Virology 440, 190-203 (2013)
Verlagsversion Volltext
DOI
PMC
HIV-1 Vpu induces downregulation of cell surface NTB-A to evade lysis of HIV-1 infected cells by NK cells. Here we show that Vpu affects the anterograde transport and the glycosylation pattern of NTB-A by a mechanism that is distinct from the Vpu induced downregulation of CD4 and tetherin. In the presence of Vpu, only the high mannose form of NTB-A was detectable, suggesting that Vpu prevented the formation of the mature form of NTB-A. This phenomenon is associated with the ability of Vpu to downregulate cell surface NTB-A by retention of NTB-A within the Golgi-compartment. Furthermore, the Vpu-mediated effect on NTB-A glycosylation is highly conserved among Vpu proteins derived from HIV-1 and SIV and corresponds to the level of downregulation of NTB-A. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Vpu ; Ntb-a ; Slamf6 ; Hiv-1 ; Siv ; Pulse-chase ; N-linked Glycosylation ; Tetherin; Virus Type-1 Vpu ; Natural-killer-cells ; Ion-channel Activity ; Down-modulation ; Membrane-protein ; Endoplasmic-reticulum ; Hiv-1-infected Cells ; Transmembrane Domain ; Cytoplasmic Domain ; Secretory Pathway
ISSN (print) / ISBN
0042-6822
e-ISSN
0042-6822
Zeitschrift
Virology
Quellenangaben
Band: 440,
Heft: 2,
Seiten: 190-203
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)