PuSH - Publikationsserver des Helmholtz Zentrums München

Takeuchi, J.K.* ; Lickert, H. ; Bisgrove, B.W.* ; Sun, X.* ; Yamamoto, M.* ; Chawengsaksophak, K.* ; Hamada, H.* ; Yost, H.J.* ; Rossant, J.* ; Bruneau, BG.*

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

Proc. Natl. Acad. Sci. U.S.A. 104, 846-851 (2007)
Verlagsversion Volltext DOI PMC
Free by publisher
Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left-right (LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF chromatin remodeling complex, is essential for establishment of LR asymmetry. Baf60c knockdown mouse embryos fail to activate Nodal at the node and also have abnormal node morphology with mixing of crown and pit cells. In cell culture, Baf60c is required for Notch-dependent transcriptional activation and functions to stabilize interactions between activated Notch and its DNA-binding partner, RBP-J. Brg1 is also required for these processes, suggesting that BAF complexes are key components of nuclear Notch signaling. We propose a critical role for Baf60c in Notch-dependent transcription and LR asymmetry.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter chromatin; Swi/Snf; node; CHROMATIN-REMODELING COMPLEX; MOUSE EMBRYO; ZEBRAFISH EMBRYO; NODAL EXPRESSION; CELL FATE; HEART; AXIS; CARDIOMYOGENESIS; TRANSACTIVATION; RECEPTORS
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 104, Heft: 3, Seiten: 846-851 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)