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Ziegler-Heitbrock, L.

The CD14+ CD16+ blood monocytes: Their role in infection and inflammation.

J. Leukoc. Biol. 81, 584-592 (2007)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of publications about CD14+ CD16+ monocytes in inflammation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter cytokines; migration; HIV; arthritis; atherosclerosis
ISSN (print) / ISBN 0741-5400
e-ISSN 1938-3673
Zeitschrift Journal of Leukocyte Biology
Quellenangaben Band: 81, Heft: 3, Seiten: 584-592 Artikelnummer: , Supplement: ,
Verlag FASEB
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)