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Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Nat. Genet. 41, 879-81 (2009)
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
transcription factor atbf1; lifetime risk; differentiation; prevalence
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Zeitschrift
Nature Genetics
Quellenangaben
Band: 41,
Heft: 8,
Seiten: 879-81
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Biological and Medical Imaging (IBMI)
Institute of Epidemiology (EPI)
Institute of Biological and Medical Imaging (IBMI)