Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
Genesis 46, 530-536 (2008)
Taking advantage of a mutant estrogen receptor ligand binding domain (ER(T2)), we developed novel Caspase fusion proteins for inducible apoptosis. We show that Caspase-ER(T2) fusion proteins become specifically activated by the synthetic ligand 4-OH- tamoxifen and rapidly induce apoptotic cell death in human, murine, and zebrafish cells. This novel tool for targeted cell ablation greatly facilitates the generation of disease models as well as developmental and regeneration studies in model organisms.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.516
0.000
11
13
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
caspase; apoptosis; tamoxifen; cell ablation; estrogen receptor
Sprache
englisch
Veröffentlichungsjahr
2008
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1526-954X
e-ISSN
1526-968X
Quellenangaben
Band: 46,
Heft: 10,
Seiten: 530-536
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Developmental Genetics (IDG)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500500-001
Scopus ID
58049083580
Erfassungsdatum
2008-12-15