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Bønnelykke, K.* ; Matheson, M.C.* ; Pers, T.H.* ; Granell, R.* ; Strachan, D.P.* ; Alves, A.C.* ; Linneberg, A.* ; Curtin, J.A.* ; Warrington, N.M.* ; Standl, M. ; Kerkhof, M.* ; Jonsdottir, I.* ; Bukvic, B.K.* ; Kaakinen, M.* ; Sleimann, P.* ; Thorleifsson, G.* ; Thorsteinsdottir, U.* ; Schramm, K. ; Baltic, S.* ; Kreiner-Møller, E.* ; Simpson, A.* ; Pourcain, B.S.* ; Coin, L.* ; Hui, J.* ; Walters, E.H.* ; Tiesler, C.M. ; Duffy, D.L.* ; Jones, G.* ; Australian Asthma Genetics Consortium (AAGC) (*) ; Ring, S.M.* ; McArdle, W.L.* ; Price, L.* ; Robertson, C.F.* ; Pekkanen, J.* ; Tang, C.S.* ; Thiering, E. ; Montgomery, G.W.* ; Hartikainen, A.L.* ; Dharmage, S.C.* ; Husemoen, L.L.* ; Herder, C.* ; Kemp, J.P.* ; Elliot, P.* ; James, A.* ; Waldenberger, M. ; Abramson, M.J.* ; Fairfax, B.P.* ; Knight, J.C.* ; Gupta, R.* ; Thompson, P.J.* ; Holt, P.* ; Sly, P.* ; Hirschhorn, J.N.* ; Blekic, M.* ; Weidinger, S.* ; Hakonarsson, H.* ; Stefansson, K.* ; Heinrich, J. ; Postma, D.S.* ; Custovic, A.* ; Pennell, C.E.* ; Jarvelin, M.R.* ; Koppelman, G.H.* ; Timpson, N.* ; Ferreira, M.A.* ; Bisgaard, H.* ; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (*) ; Henderson, A.J.*

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

Nat. Genet. 45, 902-906 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Susceptibility Loci ; Gene-expression ; Crohns-disease ; Risk Loci ; Asthma ; Variants ; Atopy ; Mechanisms ; Micrornas ; Number
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 45, Heft: 8, Seiten: 902-906 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-500700-001
G-504200-001
PubMed ID 23817571
DOI 10.1038/ng.2694
WOS ID WOS:000322374900013
Scopus ID 84881030765
Erfassungsdatum 2013-07-08
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