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ORMDL3 - guilt by association?

Clin. Exp. Allergy 38, 1579-1581 (2008)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A recent British-German study described ORMDL3 as a new asthma gene. Although the association with chromosome 17q 12 marker is plausible from earlier linkage data, it is far from being clear which gene caused the association signal, as it is derived from a large linkage disequilibrium (LD) block. Not only Aiolos and GSDML but also distant genes that are regulated by this site may be relevant. There may be even unidentified RNA transcripts requiring a much more detailed genetic and functional analysis before finding ORMDL3 guilty by association.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter allergy; asthma; gene; linkage disequilibrium; ORMDL3
ISSN (print) / ISBN 0954-7894
e-ISSN 1365-2222
Quellenangaben Band: 38, Heft: 10, Seiten: 1579-1581 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed