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Atkinson, M.J.

Radiation treatment effects on the proteome of the tumour microenvironment.

Adv. Exp. Med. Biol. 990, 49-60 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Exposure of tumourous tissue to ionizing radiation initiates a wound-healing response involving remodelling of the extracellular microenvironment. The initial reaction involves direct damage to the matrix proteins and the secretion and activation of proteolytic enzymes that lead to local destruction of the extracellular matrix. Subsequently the wounded area may undergo complete repair, may enter a prolonged period of heightened proteolysis, or may overproduce matrix proteins leading to fibrosis. The source of matrix degrading enzymatic activity may be the tumour cells and the tumour stroma. Additional complexity is provided by proteolytic activity released from tissue macrophages, mast cells and by invading inflammatory cells. The local production of growth factors, including VEGF and TGF-β play a key role in coordinating the response. It is anticipated that the application of modern proteomic technologies will reveal hitherto unrecognised levels of complexity in these processes. Hopefully this will lead to the development of new therapeutic strategies to prevent long-term health implications of radiation exposure.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Bystander Effect ; Cytokine ; Ecm ; Extracellular Matrix ; Hypoxia ; Inflammation ; Ionizing Radiation ; Lysis ; Metastasis ; Proteolysis ; Radiation Injury ; Signaling Pathways ; Stroma ; Tumour Microenvironment; Induced Lung Injury; Cell Matrix Interactions; Collagen Type-iv; Ionizing-radiation; Extracellular-matrix; In-vitro; Gene-expression; X-irradiation; Mesenchymal Transition; Radiogenic Destruction
ISSN (print) / ISBN 0065-2598
Zeitschrift Advances in Experimental Medicine and Biology
Quellenangaben Band: 990, Heft: , Seiten: 49-60 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)