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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cationic thermosensitive liposomes: A novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells.
Nano Lett. 13, 2324-2331 (2013)
Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing liposomes combining cationic charged and thermosensitive lipids in the bilayer. We demonstrated, using flow cytometry, live cell imaging, and intravital optical imaging, that cationic thermosensitive liposomes specifically target angiogenic endothelial and tumor cells. Application of mild hyperthermia led to a rapid content release extra- and intracellularly in two crucial cell types in a solid tumor.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cationic Thermosensitive Liposomes; Hyperthermia; Triggered Release; Drug Delivery; Targeted Nanomedicine; Anionic Phospholipids ; Vascular-permeability ; Content Release ; Solid Tumors ; In-vitro ; Doxorubicin ; Hyperthermia ; Trial ; Anthracyclines ; Therapeutics
ISSN (print) / ISBN
1530-6984
e-ISSN
1530-6992
Zeitschrift
Nano Letters
Quellenangaben
Band: 13,
Heft: 6,
Seiten: 2324-2331
Verlag
American Chemical Society (ACS)
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)