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Ellinghaus, D.* ; Folseraas, T.* ; Holm, K.* ; Ellinghaus, E.* ; Melum, E.* ; Balschun, T.* ; Laerdahl, J.K.* ; Shiryaev, A.* ; Gotthardt, D.N.* ; Weismüller, T.J.* ; Schramm, C.* ; Wittig, M.* ; Bergquist, A.* ; Björnsson, E.* ; Marschall, H.U.* ; Vatn, M.* ; Teufel, A.* ; Rust, C.* ; Gieger, C. ; Wichmann, H.-E. ; Runz, H.* ; Sterneck, M.* ; Rupp, C.* ; Braun, F.* ; Weersma, R.K.* ; Wijmenga, C.* ; Ponsioen, C.Y.* ; Mathew, C.G.* ; Rutgeerts, P.* ; Vermeire, S.* ; Schrumpf, E.* ; Hov, J.R.* ; Manns, M.P.* ; Boberg, K.M.* ; Schreiber, S.* ; Franke, A.* ; Karlsen, T.H.*

Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.

Hepatology 58, 1074-1083 (2013)
Verlagsversion Volltext DOI PMC
Open Access Gold
Approximately 60%-80% of patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). Previous genome-wide association studies (GWAS) in PSC have detected a number of susceptibility loci that also show associations in UC and other immune-mediated diseases. We aimed to systematically compare genetic associations in PSC with genotype data in UC patients with the aim of detecting new susceptibility loci for PSC. We performed combined analyses of GWAS for PSC and UC comprising 392 PSC cases, 987 UC cases, and 2,977 controls and followed up top association signals in an additional 1,012 PSC cases, 4,444 UC cases, and 11,659 controls. We discovered novel genome-wide significant associations with PSC at 2q37 [rs3749171 at G-protein-coupled receptor 35 (GPR35); P = 3.0 × 10(-9) in the overall study population, combined odds ratio [OR] and 95% confidence interval [CI] of 1.39 (1.24-1.55)] and at 18q21 [rs1452787 at transcription factor 4 (TCF4); P = 2.61 × 10(-8) , OR (95% CI) = 0.75 (0.68-0.83)]. In addition, several suggestive PSC associations were detected. The GPR35 rs3749171 is a missense single nucleotide polymorphism resulting in a shift from threonine to methionine. Structural modeling showed that rs3749171 is located in the third transmembrane helix of GPR35 and could possibly alter efficiency of signaling through the GPR35 receptor. Conclusion: By refining the analysis of a PSC GWAS by parallel assessments in a UC GWAS, we were able to detect two novel risk loci at genome-wide significance levels. GPR35 shows associations in both UC and PSC, whereas TCF4 represents a PSC risk locus not associated with UC. Both loci may represent previously unexplored aspects of PSC pathogenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Inflammatory-bowel-disease; Transcription Factor E2-2; Susceptibility Loci; Lymphocyte Development; Genes
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0270-9139
e-ISSN 1527-3350
Zeitschrift Hepatology
Quellenangaben Band: 58, Heft: 3, Seiten: 1074-1083 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken, NJ
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-504100-001
PubMed ID 22821403
DOI 10.1002/hep.25977
WOS ID WOS:000329284000028
Scopus ID 84883219528
Erfassungsdatum 2013-07-31
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