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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Current frontiers in clinical research application of MALDI imaging mass spectrometry.
Expert Rev. Proteomics 10, 259-273 (2013)
Imaging mass spectrometry (IMS) is still a relatively young imaging technique that allows molecular mapping of diverse biomolecules in their natural environment. Furthermore, IMS allows for the direct correlation of tissue histology and proteomic, metabolomic or lipidomic information. In recent years, increasing efforts have been made in the development and improvement of IMS, which aid its application in clinical research. In this article, current frontiers of clinical research applications of IMS are discussed in the context of recent developments of IMS technology. Critical stages in planning and realizing clinical studies are highlighted. Finally, a selection of recent prominent examples for successful clinical applications of IMS is presented.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Clinical Proteomics ; Imaging Mass Spectrometry ; Maldi Imaging Mass Spectrometry ; Molecular Pathology ; Tissue Protein Analysis; Paraffin-embedded Tissue ; Matrix Application Method ; In-source Decay ; Breast-cancer ; Biomarker Discovery ; Protein Expression ; Drug Distribution ; Gastric-cancer ; Mouse-brain ; Intratumor Heterogeneity
ISSN (print) / ISBN
1478-9450
e-ISSN
1744-8387
Zeitschrift
Expert Review of Proteomics
Quellenangaben
Band: 10,
Heft: 3,
Seiten: 259-273
Verlag
Expert Reviews
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed