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Argonaute and GW182 proteins: An effective alliance in gene silencing.
Biochem. Soc. Trans. 41, 855-860 (2013)
Argonaute proteins interact with small RNAs and facilitate small RNA-guided gene-silencing processes. Small RNAs guide Argonaute proteins to distinct target sites on mRNAs where Argonaute proteins interact with members of the GW182 protein family (also known as GW proteins). In subsequent steps, GW182 proteins mediate the downstream steps of gene silencing. The present mini-review summarizes and discusses our current knowledge of the molecular basis of Argonaute-GW182 protein interactions.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Argonaute proteine; Gene silencing; GW182 protein; microRNA; miRNA; RNA interference; RNAi; Messenger-rna Degradation ; Crystal-structure ; Structural Basis ; Guide Rna ; Translational Repression ; Piwi-domain ; Paz Domain ; Human Ago2 ; Gw Bodies ; P-bodies
ISSN (print) / ISBN
0300-5127
e-ISSN
1470-8752
Zeitschrift
Biochemical Society Transactions
Quellenangaben
Band: 41,
Heft: 4,
Seiten: 855-860
Verlag
Portland Press
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Structural Biology (STB)