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Protein annotation at genomic scale: the current status.
Chem. Rev. 107, 3448-3466 (2007)
Genomic sequence must be associated with the course of genome annotation for it to become useful and comprehensible. Annotation are notes that contain information about the cellular role and mechanism of action of genes and their products. However, they are both faced with quantitative and qualitative challenges. Quantitative in the sense that it is quite impossible to annotate all proteins with our available resources, while facing qualitative problem as there will be no experimental evidence to annotate. Thus, the current status of modern procedures that are used for manual genome annotation are presented. In addition, computational methods and software infrastructure are also discussed which are used for analyzing protein function. Processes on the reduction of error level of automatically generated annotation are also described. Lastly, problems in gene prediction with the focus on improving the quality of functional inference are also detailed.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
26.054
12.809
44
50
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2007
HGF-Berichtsjahr
2007
ISSN (print) / ISBN
0009-2665
e-ISSN
1520-6890
Zeitschrift
Chemical Reviews
Quellenangaben
Band: 107,
Heft: 8,
Seiten: 3448-3466
Verlag
American Chemical Society (ACS)
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-503700-001
PubMed ID
17658902
WOS ID
000248657400007
Scopus ID
34548246519
Erfassungsdatum
2007-07-21