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Anttila, V.* ; Winsvold, B.S.* ; Gormley, P.* ; Kurth, T.* ; Bettella, F.* ; McMahon, G.* ; Kallela, M.* ; Malik, R.* ; de Vries, B.* ; Terwindt, G.* ; Medland, S.E.* ; Todt, U.* ; McArdle, W.L.* ; Quaye, L.* ; Koiranen, M.* ; Ikram, M.A.* ; Lehtimäki, T.* ; Stam, A.H.* ; Ligthart, L.* ; Wedenoja, J.* ; Dunham, I.* ; Neale, B.M.* ; Palta, P.* ; Hämäläinen, E.* ; Schürks, M.* ; Rose, L.M.* ; Buring, J.E.* ; Ridker, P.M.* ; Steinberg, S.* ; Stefansson, H.* ; Jakobsson, F.* ; Lawlor, D.A.* ; Evans, D.M* ; Ring, S.M.* ; Färkkilä, M.* ; Artto, V.* ; Kaunisto, M.A.* ; Freilinger, T.* ; Schoenen, J.* ; Frants, R.R.* ; Pelzer, N.* ; Weller, C.M.* ; Zielman, R.* ; Heath, A.C.* ; Madden, P.A.* ; Montgomery, G.W.* ; Martin, N.G.* ; Borck, G.* ; Göbel, H.* ; Heinze, A.* ; Heinze-Kuhn, K.* ; Williams, F.M.* ; Hartikainen, A.L.* ; Pouta, A.* ; van den Ende, J.* ; Uitterlinden, A.G.* ; Hofman, A.* ; Amin, N.* ; Hottenga, J.J.* ; Vink, J.M.* ; Heikkilä, K.* ; Alexander, M.* ; Müller-Myhsok, B.* ; Schreiber, S.* ; Meitinger, T. ; Wichmann, H.-E. ; Aromaa, A.* ; Eriksson, J.G.* ; Traynor, B.J.* ; Trabzuni, D.* ; North American Brain Expression Consortium (*) ; UK Brain Expression Consortium (*) ; Rossin, E.* ; Lage, K.* ; Jacobs, S.B.* ; Gibbs, J.R.* ; Birney, E.* ; Kaprio, J.* ; Penninx, B.W.* ; Boomsma, D.I.* ; van Duijn, C.M.* ; Raitakari, O.* ; Jarvelin, M.R.* ; Zwart, J.A.* ; Cherkas, L.* ; Strachan, D.P.* ; Kubisch, C.* ; Ferrari, M.D.* ; van den Maagdenberg, A.M.* ; Dichgans, M.* ; Wessman, M.* ; Smith, G.D.* ; Stefansson, K.* ; Daly, M.J.* ; International Headache Genetics Consortium (*) ; Nyholt, D.R.* ; Chasman, D.I.* ; Palotie, A.*

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Nat. Genet. 45, 912-917 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Transforming-growth-factor ; Neurite Outgrowth ; Down-regulation ; Human-disease ; Association ; Expression ; Protein ; Family ; Proteolysis ; Population
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 45, Heft: 8, Seiten: 912-917 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)