möglich sobald bei der ZB eingereicht worden ist.
Expansion von T-Zellen seltener Spezifität mittels B-Zellen.
München, Ludwig-Maximilians-Universität, Fakultät für Chemie und Pharmazie, Diss., 2004, 105 S.
I concentrated on the expansion of T cells specific against the oncogenic human papilloma virus 16 (HPV16), which are a very rare population in the blood of healthy donors as well as patients with HPV16-associated cancer. Instead of mature dendritic cells (DC) as antigen presenting cells, which are a potent but limitated system, I used activated B cells. I was able to expand cytotoxic active HPV-specific T cells to therapeutically relevant cell numbers. I analysed the T cell receptors of the E7-specific T cells well as their avidity to get a first idea of clonality and avidity of HPV-specific T cell pools.
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Sonstiges: Hochschulschrift
Typ der Hochschulschrift
Dissertationsschrift
Schlagwörter
HPV; T cells; B cells; EBV; adoptive therapy; CD40L
Quellenangaben
Seiten: 105 S.
Hochschule
Ludwig-Maximilians-Universität
Hochschulort
München
Fakultät
Fakultät für Chemie und Pharmazie
Institut(e)
Research Unit Gene Vector (AGV)