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The role of dendritic cells in autoimmunity.
Nat. Rev. Immunol. 13, 566-577 (2013)
Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses. Accordingly, recent evidence from clinical studies and experimental models implicates DCs in the pathogenesis of most autoimmune diseases. However, fundamental questions remain unanswered concerning the actual roles of DCs in autoimmunity, both in general and, in particular, in specific diseases. In this Review, we discuss the proposed roles of DCs in immunological tolerance, the effect of the gain or loss of DCs on autoimmunity and DC-intrinsic molecular regulators that help to prevent the development of autoimmunity. We also review the emerging roles of DCs in several autoimmune diseases, including autoimmune myocarditis, multiple sclerosis, psoriasis, type 1 diabetes and systemic lupus erythematosus.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Regulatory T-cells ; Alpha-producing Cells ; Systemic-lupus-erythematosus ; Peripheral Self-tolerance ; Nonobese Diabetic Mouse ; Cytokine Gm-csf ; In-vivo ; Nod Mice ; Mediated Autoimmunity ; Multiple-sclerosis
ISSN (print) / ISBN
1474-1733
e-ISSN
1474-1741
Zeitschrift
Nature Reviews - Immunology
Quellenangaben
Band: 13,
Heft: 8,
Seiten: 566-577
Verlag
Nature Publishing Group
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)