PuSH - Publikationsserver des Helmholtz Zentrums München

Luz, A. ; Krump-Konvalinkova, V. ; Snell, G. ; Strauss, P.G. ; Höfler, H. ; Erfle, V. ; Schmidt, J.

Das murine Leukämievirus Akv wirkt als Promoter der Knochentumorentwicklung fos-transgener Mäuse.

Murine leukemia virus Akv promotes bone tumor development in fos-transgenic mice.

Verh. Dtsch. Ges. Pathol. 78, 265-269 (1994)
PMC
Newborn hMT-fos-LTR transgenic C3H mice and their non-transgenic siblings were infected with Akv, derived from the ecotropic provirus of the AKR mouse. Bone sarcomas in non-infected transgenics were observed in 20% (3/15) of females at 448 +/- 25 days and in 8% (1/12) of males at 523 days. Akv-infected transgenics developed bone tumors with higher frequency and at younger age: Females in 69% (20/28) at 268 +/- 122 days, males in 83% (24/29) at 279 +/- 109 days. In the majority of the bone tumors of Akv-infected transgenics (70% in females, 59% in males) cellular atypia was lacking and the histological pattern resembled human parosteal osteosarcoma. Only 50% (12/24) of bone tumors in Akv-infected transgenics revealed newly integrated virus sequences by Southern analysis. PCR analysis detected Akv sequences in DNAs of all tumors. Obviously, the insertion of Akv in a few cells induced the considerably accelerated bone tumor growth.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0070-4113
Zeitschrift Verhandlungen der Deutschen Gesellschaft für Pathologie
Quellenangaben Band: 78, Heft: , Seiten: 265-269 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)