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Hara, K.* ; Fujita, H.* ; Johnson, T.A.* ; Yamauchi, T.* ; Yasuda, K.* ; Horikoshi, M.* ; Peng, C.* ; Hu, C.* ; Ma, R.C.* ; Imamura, M.* ; Iwata, M.* ; Tsunoda, T.* ; Morizono, T.* ; Shojima, N.* ; So, W.Y.* ; Leung, T.F.* ; Kwan, P.* ; Zhang, R.* ; Wang, J.* ; Yu, W.* ; Maegawa, H.* ; Hirose, H.* ; DIAGRAM Consortium (Huth, C. ; Gieger, C. ; Klopp, N. ; Meitinger, T. ; Illig, T. ; Grallert, H. ; Thorand, B. ; Wichmann, H.-E. ; Petersen, A.-K.) ; Kaku, K.* ; Ito, C.* ; Watada, H.* ; Tanaka, Y.* ; Tobe, K.* ; Kashiwagi, A.* ; Kawamori, R.* ; Jia, W.* ; Chan, J.C.* ; Teo, Y.Y.* ; Shyong, T.E.* ; Kamatani, N.* ; Kubo, M.* ; Maeda, S.* ; Kadowaki, T.*

Genome-wide association study identifies three novel loci for type 2 diabetes.

Hum. Mol. Genet. 23, 239-246 (2014)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were selected and taken forward to follow-up analyses. Combined discovery and follow-up analyses (30 392 cases and 34 814 controls) identified three new loci with genome-wide significance, which were MIR129-LEP [rs791595; risk allele = A; risk allele frequency (RAF) = 0.080; P = 2.55 × 10(-13); odds ratio (OR) = 1.17], GPSM1 [rs11787792; risk allele = A; RAF = 0.874; P = 1.74 × 10(-10); OR = 1.15] and SLC16A13 (rs312457; risk allele = G; RAF = 0.078; P = 7.69 × 10(-13); OR = 1.20). This study demonstrates that GWASs based on the imputation of genotypes using modern reference haplotypes such as that from the 1000 Genomes Project data can assist in identification of new loci for common diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter East-asian Populations; Susceptibility Loci; Insulin-resistance; Beta-cell; Variants; Transporters; Metaanalysis; Mellitus; Diseases; Obesity
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 23, Heft: 1, Seiten: 239-246 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology II (EPI2)
Institute of Genetic Epidemiology (IGE)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
German Center for Diabetes Reseach (DZD)