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Hinney, A.* ; Wolters, B.* ; Pütter, C.* ; Grallert, H. ; Illig, T. ; Hebebrand, J.* ; Reinehr, T.*

No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children.

J. Pediatr. Endocrinol. Metab. 26, 1209-1213 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Abstract Objective: An obesity risk allele at the NEGR1 locus was shown to be associated with weight regain after a lifestyle intervention in obese adults. Independent confirmation and studies in children are lacking. Therefore, we analyzed the impact of this and 11 additional obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children. Design and Methods: We longitudinally analyzed the changes in weight status as body mass index standard deviation score (BMI-SDS) in 282 overweight children (10.6±2.5 years, 47% male, BMI 27.1±3.9 kg/m2) both at the end of a 1-year lifestyle intervention and at 1 year after the end of intervention. We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15. Results: The children reduced their BMI-SDS (-0.28±0.35; p<0.001) during intervention and increased their BMI-SDS between the end of intervention and 1 year later (+0.05±0.36; p=0.027). None of the SNPs including NEGR1 was related significantly to weight regain. Conclusions: We found no evidence for effects of any of the GWAS-based obesity marker alleles on weight regain in the course of 1 year after an intervention.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Children; Lifestyle intervention; Obesity; SNPs; Weight gain; Body-mass Index ; Diabetes Prevention Program ; Adolescents ; Insig2 ; Gene
ISSN (print) / ISBN 0334-018X
e-ISSN 2191-0251
Zeitschrift Journal of Pediatric Endocrinology and Metabolism
Quellenangaben Band: 26, Heft: 11-12, Seiten: 1209-1213 Artikelnummer: , Supplement: ,
Verlag de Gruyter
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Epidemiology (AME)
CCG Biomarker for the subclassification of T2DM (KKG-KDB)