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Dastani, Z.* ; Johnson, T.* ; Kronenberg, F.* ; Nelson, C.P.* ; Assimes, T.L.* ; Marz, W.* ; CARDIoGRAM Consortium (Wichmann, H.-E. ; Döring, A. ; Illig, T. ; Klopp, N. ; Peters, A. ; Meisinger, C. ; Meitinger, T.) ; ADIPOGen Consortium (*) ; Richards, J.B.*

The shared allelic architecture of adiponectin levels and coronary artery disease.

Atherosclerosis 229, 145-148 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
OBJECTIVE: A large body of epidemiologic data strongly suggests an association between excess adiposity and coronary artery disease (CAD). Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in observational studies. However, these associations cannot clarify whether this relationship is causal or due to a shared set of causal factors or even confounding. Genome-wide association studies have identified common variants that influence adiponectin levels, providing valuable tools to examine the genetic relationship between adiponectin and CAD. METHODS: Using 145 genome wide significant SNPs for adiponectin from the ADIPOGen consortium (n = 49,891), we tested whether adiponectin-decreasing alleles influenced risk of CAD in the CARDIoGRAM consortium (n = 85,274). RESULTS: In single-SNP analysis, 5 variants among 145 SNPs were associated with increased risk of CAD after correcting for multiple testing (P < 4.4 × 10(-4)). Using a multi-SNP genotypic risk score to test whether adiponectin levels and CAD have a shared genetic etiology, we found that adiponectin-decreasing alleles increased risk of CAD (P = 5.4 × 10(-7)). CONCLUSION: These findings demonstrate that adiponectin levels and CAD have a shared allelic architecture and provide rationale to undertake a Mendelian randomization studies to understand if this relationship is causal.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0021-9150
e-ISSN 1879-1484
Zeitschrift Atherosclerosis
Quellenangaben Band: 229, Heft: 1, Seiten: 145-148 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Research Unit Molecular Epidemiology (AME)
Institute of Human Genetics (IHG)