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Kohlboeck, G. ; Romanos, M.* ; Tiesler, C.M. ; Koletzko, S.* ; Kratzsch, J.* ; Thiery, J.* ; Bauer, C.P.* ; von Berg, A.* ; Berdel, D.* ; Hoffmann, B.* ; Schaaf, B.* ; Lehmann, I.* ; Herbarth, O.* ; Heinrich, J. ; GINIplus Study Group (Heinrich, J. ; Wichmann, H.-E.) ; LISAplus Study Group (Heinrich, J. ; Wichmann, H.-E.)

Peer problems are associated with elevated serum leptin levels in children.

Psychol. Med. 44, 255-265 (2014)
Verlagsversion DOI PMC
Open Access Gold
BACKGROUND: Leptin is thought to act as an important mediator in stress reactions. To date, no study has examined the association between psychological stress and leptin levels in children. This study aimed to assess the association between emotional symptoms and peer problems and serum leptin levels in children aged 10 years of the two population-based GINI-plus and LISA-plus birth cohorts. Method Cross-sectional data from 2827 children aged 10 years were assessed with regard to leptin concentrations in serum and behavioral problems using the parent-reported Strengths and Difficulties Questionnaire (SDQ). Linear regression modeling was applied to determine the likelihood of elevated leptin levels in children with emotional symptoms and peer problems, controlling for socio-economic status (SES), body mass index (BMI), fasting serum leptin levels, pubertal development and sex hormones. RESULTS: We found that increases in emotional symptoms (exp β adj = 1.03, s.e. = 0.02, p < 0.04) and peer problems (exp β adj = 1.05, s.e. = 0.01, p = 0.0001) were significantly associated with higher serum leptin levels controlled for BMI and sociodemographic factors. Similar results were found when the fasting serum leptin sample was examined (exp β adj = 1.08, s.e. = 0.04, p = 0.0294). Gender-stratified analyses showed a significant relationship between serum leptin and peer problems in girls (exp β adj = 1.05, s.e. = 0.02, p = 0.03), and a borderline significant association in boys (exp β adj = 1.04, s.e. = 0.02, p = 0.05). CONCLUSIONS: Children with peer problems have higher stress and eat more, acquire a higher body fat mass and thus, through increased leptin resistance, exhibit higher leptin levels.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Epidemiology ; Hpa Axis ; Peer Relationship Problems ; Leptin ; Obesity ; Depression ; Behavior Problems ; Stress ; Psychopathology; Body-mass Index; Plasma Leptin; Anorexia-nervosa; Gonadal-hormones; Healthy-children; Pubertal Status; Diurnal Rhythm; Birth Cohort; Food-intake; Fat Mass
Sprache
Veröffentlichungsjahr 2014
Prepublished im Jahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0033-2917
e-ISSN 1469-8978
Zeitschrift Psychological Medicine
Quellenangaben Band: 44, Heft: 2, Seiten: 255-265 Artikelnummer: , Supplement: ,
Verlag Cambridge University Press
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
DOI 10.1017/S003329171300069X
WOS ID WOS:000332382900004
Scopus ID 84890609392
PubMed ID 23561045
Erfassungsdatum 2013-11-13
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