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Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion.
J. Immunol. 163, 6762-6768 (1999)
Vaccinia virus employs multiple mechanisms to evade the immune system, yet is highly immunogenic. We studied the interaction between vaccinia and human dendritic cells (DCs), potent APCs. DCs develop from precursor cells in two stages: an immature stage in which Ag uptake and processing occur, and a mature stage in which there is up-regulation of costimulatory and HLA molecules and efficient T cell activation. Vaccinia virus undergoes an abortive replication in both stages of DCs and induces apoptotic cell death. Furthermore, maturation of immature DCs and consequently T cell activation are inhibited. Obstruction of DC maturation may constitute a novel mechanism by which vaccinia attempts to evade the immune response.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0022-1767
e-ISSN
1550-6606
Zeitschrift
Journal of Immunology
Quellenangaben
Band: 163,
Heft: 12,
Seiten: 6762-6768
Verlag
American Association of Immunologists
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Immunology (IMI)