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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Identification and functional validation of novel autoantigens in equine uveitis.
Mol. Cell. Proteomics 5, 1462-1470 (2006)
The development, progression, and recurrence of autoimmune diseases are frequently driven by a group of participatory autoantigens. We identified and characterized novel autoantigens by analyzing the autoantibody binding pattern from horses affected by spontaneous equine recurrent uveitis to the retinal proteome. Cellular retinaldehyde-binding protein (cRALBP) had not been described previously as autoantigen, but subsequent characterization in equine recurrent uveitis horses revealed B and T cell autoreactivity to this protein and established a link to epitope spreading. We further immunized healthy rats and horses with cRALBP and observed uveitis in both species with typical tissue lesions at cRALBP expression sites. The autoantibody profiling outlined here could be used in various autoimmune diseases to detect autoantigens involved in the dynamic spreading cascade or serve as predictive markers. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
1535-9476
e-ISSN
1535-9484
Zeitschrift
Molecular and Cellular Proteomics
Quellenangaben
Band: 5,
Heft: 8,
Seiten: 1462-1470
Verlag
American Society for Biochemistry and Molecular Biology
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)