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Flaquer, A. ; Heinzmann, A.* ; Rospleszcz, S. ; Mailaparambil, B.* ; Dietrich, H.* ; Strauch, K. ; Grychtol, R.*

Association study of mitochondrial genetic polymorphisms in asthmatic children.

Mitochondrion 14, 49-53 (2014)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
It has been suggested that mitochondrial dysfunction plays a role in the pathogenesis of asthma. To test whether mitochondrial variants influence the risk of asthma, we analyzed 16,158 mtSNPs in a sample of 372 asthmatic children and 395 healthy children using the DNA pooling technique and genome wide association analysis. Stratified analysis by sex was performed to explain the differences observed between sexes in the etiology of asthma. Different variants were detected to be significant in the sample of girls and boys with the smallest adjusted P values being 1.4x10(-09) (mt5295) and 3.6x10(-12) (mt16158), respectively. Most of the significant locations found in boys are within the CYB gene and the non-coding region. For girls, most of the significant mtSNPs lie within NADH-dehydrogenase-subunits. The variants reported here have not previously been described in connection with asthma. Although further studies in other cohorts are needed to confirm these findings our study highlights the importance of the mitochondria among the factors that contribute to the risk of asthma.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Asthma ; Genome Wide Association ; Mitochondrial Genome ; Pool Data; Hereditary Optic Neuropathy; Dna Control Region; High-throughput; Mutations; Arrays; Pools; Transcription; Replication; Dysfunction; Microarrays
Sprache englisch
Veröffentlichungsjahr 2014
Prepublished im Jahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1567-7249
e-ISSN 1872-8278
Zeitschrift Mitochondrion
Quellenangaben Band: 14, Heft: 1, Seiten: 49-53 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
PubMed ID 24270090
DOI 10.1016/j.mito.2013.11.002
WOS ID WOS:000330912200007
Scopus ID 84892950699
Erfassungsdatum 2013-11-27
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