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Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy.
Chem. Sci. 4, 3148-3153 (2013)
A series of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3,4-diamino-3-cyclobutene-1,2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170–176% enhancements in relaxation rate, following incubation with a neuronal cell line model. A derivative of the lead compound was prepared containing a biotin moiety, and both the specificity and reversibility of binding to the NMDA cell surface receptors demonstrated using confocal microscopy.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
2041-6520
e-ISSN
2041-6539
Zeitschrift
Chemical Science
Quellenangaben
Band: 4,
Seiten: 3148-3153
Verlag
Royal Society of Chemistry (RSC)
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed