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Dahlhoff, M.* ; Pfister, S.* ; Blutke, A.* ; Rozman, J. ; Klingenspor, M.* ; Deutsch, M.J.* ; Rathkolb, B. ; Fink, B.* ; Gimpfl, M.* ; Hrabě de Angelis, M. ; Roscher, A.A.* ; Wolf, E.* ; Ensenauer, R.*

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

Biochim. Biophys. Acta-Mol. Basis Dis. 1842, 304–317 (2014)
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Vulnerability of the fetus upon maternal obesity can potentially occur during all developmental phases. We aimed at elaborating longer-term health outcomes of fetal overnutrition during the earliest stages of development. We utilized NMRI mice to induce pre-conceptional and gestational obesity and followed offspring outcomes in the absence of any postnatal obesogenic influences. Male adult offspring developed overweight, insulin resistance, hyperleptinemia, hyperuricemia and hepatic steatosis; all these features not being observed in females. Instead, those showed impaired fasting glucose and a reduced fat mass and adipocyte size. Influences of the interaction of maternal diet*sex concerned offspring genes involved in fatty liver disease, lipid droplet size regulation and fat mass expansion. These data suggest that a peri-conceptional obesogenic exposure is sufficient to shape offspring gene expression patterns and health outcomes in a sex- and organ-specific manner, indicating varying developmental vulnerabilities between sexes towards metabolic disease in response to maternal overnutrition.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Obesity ; Peri-conceptional ; Pregnancy ; Offspring ; Programming ; Sex-specificity; High-fat Diet; Maternal Obesity; Adipose-tissue; Insulin-resistance; Leptin Resistance; Gene-expression; Adipocyte Size; Liver-disease; Mice; Pregnancy
Sprache englisch
Veröffentlichungsjahr 2014
Prepublished im Jahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0925-4439
e-ISSN 1878-2434
Zeitschrift Biochimica et Biophysica Acta - Molecular Basis of Disease
Quellenangaben Band: 1842, Heft: 2, Seiten: 304–317 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500600-003
G-500600-001
G-501900-063
G-501900-066
PubMed ID 24275555
DOI 10.1016/j.bbadis.2013.11.021
WOS ID WOS:000331414900019
Scopus ID 84890879744
Erfassungsdatum 2013-11-28
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