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Daniel, C. ; Gerlach, K.* ; Väth, M.* ; Neurath, M.F.* ; Weigmann, B.*

Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer.

Int. J. Cancer 134, 1767-1775 (2014)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation-associated colorectal cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nuclear Factor of activated T celss; Cancer; Transcription factor; Colitis-associated Cancer; Factor Nfatc2 Controls; Nf-kappa-b; Pancreatic-cancer; Gene-expression; Cyclosporine-a; C-rel; Histone Acetylation; Signaling Pathway; Prostate-cancer
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Zeitschrift International Journal of Cancer
Quellenangaben Band: 134, Heft: 8, Seiten: 1767-1775 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
German Center for Diabetes Reseach (DZD)