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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer.
Int. J. Cancer 134, 1767-1775 (2014)
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation-associated colorectal cancer.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Nuclear Factor of activated T celss; Cancer; Transcription factor; Colitis-associated Cancer; Factor Nfatc2 Controls; Nf-kappa-b; Pancreatic-cancer; Gene-expression; Cyclosporine-a; C-rel; Histone Acetylation; Signaling Pathway; Prostate-cancer
ISSN (print) / ISBN
0020-7136
e-ISSN
1097-0215
Zeitschrift
International Journal of Cancer
Quellenangaben
Band: 134,
Heft: 8,
Seiten: 1767-1775
Verlag
Wiley
Verlagsort
Hoboken
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes Research (IDF)
German Center for Diabetes Reseach (DZD)
German Center for Diabetes Reseach (DZD)