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Okada, Y.* ; Kubo, M.* ; Ohmiya, H.* ; Takahashi, A.* ; Kumasaka, N.* ; Hosono, N.* ; Maeda, S.* ; Wen, W.* ; Dorajoo, R.* ; Go, M.J.* ; Zheng, W.* ; Kato, N.* ; Wu, J.Y.* ; Lu, Q.* ; GIANT Consortium (Heid, I.M. ; Thiering, E. ; Gieger, C. ; Grallert, H. ; Heinrich, J. ; Illig, T. ; Peters, A. ; Wichmann, H.-E.) ; Tsunoda, T.* ; Yamamoto, K.* ; Nakamura, Y.* ; Kamatani, N.* ; Tanaka, T.*

Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations.

Nat. Genet. 44, 302-306 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index-associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 × 10(-11)) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 × 10(-9)), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 × 10(-8)). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 × 10(-8)) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 44, Heft: 3, Seiten: 302-306 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30201 - Metabolic Health
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
G-503900-001
G-521500-002
G-504000-002
G-504200-002
PubMed ID 22344221
DOI 10.1038/ng.1086
Erfassungsdatum 2013-12-11
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